WHICH ACUTE AND INTERMEDIATE SYMPTOMS RESPOND TO HRT?

Studies have consistently reported that estrogens relieve mention 2 symptoms, sleeplessness and the local symptoms of vaginal atrophy. With regard to the psychological status, the reported benefits vary widely.

HOW QUICKLY CAN RELIEF OF FLUSHES BE ACHIEVED?

The response to treatment can be dramatic with a marked effect obvious within a few days and elimination of flushing achieved within a few weeks.

DO THESE BENEFITS LAST LONG?

Yes. Once stabilized on HRT, symptom relief is usually sustained throughout the treatment period. Various factors, however, result in a partial return of vasomotor symptoms. These include travelling in the sun during the summer holidays, prolonged use of certain antibiotics and domestic or work stress. Abrupt cessation of HRT often results in a return of flushes and sweats. This can be avoided by a gradual reduction in estrogen dosage over several weeks or months as recommended by your physician.

WHICH PSYCHOLOGICAL SYMPTOMS RESPOND TO HRT?

There is a significant decrease in psychological complaints such as irritability, fatigue, anxiety and depression when estrogen is given alone or in combination with a progestogen. It is felt that the psychological improvements are secondary to the relief of disabling vasomotor symptoms, i.e. the 'domino effect'.

The benefits observed in women, who do not get hot flushes, also suggest a direct positive effect of estrogen on the mental status.